Abstract: Comparison of cyclizine and ondansetron for the prevention of postoperative nausea and vomiting in laparoscopic day-case gynaecological surgery.
Grimsehl K, Whiteside JB, Mackenzie N.
Anaesthetics, Ninewells Hospital, Dundee DD1 9SY, UK.
Anaesthesia. 2002 Jan;57(1):61-5.
Seventy-four patients undergoing laparoscopic gynaecological
surgery were randomly allocated to two groups receiving cyclizine
50 mg or ondansetron 4 mg at induction of anaesthesia. Anaesthetic
and postoperative analgesia regimens were standardised.
Approximately half of the patients in each group experienced some
degree of postoperative nausea and vomiting (cyclizine, 56%;
ondansetron, 54%). There was no difference between groups in
respect of pre- and postdischarge incidence. Mean (SD) time to eye
opening was significantly prolonged in the cyclizine group [10 (4)
min vs. 8 (2) min; p < 0.001], but this had no influence on
discharge times. Cyclizine and ondansetron appear equally effective
in preventing postoperative nausea and vomiting but the 10-fold
price differential favours cyclizine.
Anaesthesia Complications PONV Gynaecology Surgery Laparoscopy