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Abstract: A comparison of target-controlled therapy with patient-controlled administration of propofol combined with midazolam for sedation during dental surgery


Burns R, McCrae AF, Tiplady B.


Department of Anaesthetics, Royal Infirmary of Edinburgh, UK.


Anaesthesia. 2003 Feb;58(2):170-6.


Forty anxious day case patients undergoing extraction of third molar teeth under local anaesthesia with sedation, were studied in a randomised double-blind controlled trial. A target-controlled infusion of propofol was compared with patient-controlled propofol for sedation, combined with a small dose of midazolam to improve amnesia. The objectives of the study were to measure the total dose of propofol used by the two groups and assess recovery and patient satisfaction. The mean dose of propofol used in the patient-controlled sedation group was significantly less than the target-controlled group (p < 0.00007). Five patients became over-sedated in the target-controlled group compared with none in the patient-controlled group. Only one of the three tests of performance showed that the target-controlled patients were more sedated. Patient satisfaction was high in both groups despite a greater recollection of events in the patient-controlled group.


Oral Surgery Extraction Anaesthesia Sedation Midazolam Propofol